Modular Integration of Hydrogel Neural Interfaces

Abstract

Thermal drawing has been recently leveraged to yield multifunctional, fiber-based neural probes at near kilometer length scales. Despite its promise, the widespread adoption of this approach has been impeded by (1) material compatibility requirements and (2) labor-intensive interfacing of functional features to external hardware. Furthermore, in multifunctional fibers, significant volume is occupied by passive polymer cladding that so far has only served structural or electrical insulation purposes. In this article, we report a rapid, robust, and modular approach to creating multifunctional fiber-based neural interfaces using a solvent evaporation or entrapment-driven (SEED) integration process. This process brings together electrical, optical, and microfluidic modalities all encased within a copolymer comprised of water-soluble poly(ethylene glycol) tethered to water-insoluble poly(urethane) (PU-PEG). We employ these devices for simultaneous optogenetics and electrophysiology and demonstrate that multifunctional neural probes can be used to deliver cellular cargo with high viability. Upon exposure to water, PU-PEG cladding spontaneously forms a hydrogel, which in addition to enabling integration of modalities, can harbor small molecules and nanomaterials that can be released into local tissue following implantation. We also synthesized a custom nanodroplet forming block polymer and demonstrated that embedding such materials within the hydrogel cladding of our probes enables delivery of hydrophobic small molecules in vitro and in vivo. Our approach widens the chemical toolbox and expands the capabilities of multifunctional neural interfaces.

Publication
ACS Central Science
Anthony Tabet
Anthony Tabet
Graduate Student

Full-time graduate student | aspiring standup comedian

Marc-Joseph Antonini
Marc-Joseph Antonini
Postdoctoral Associate

Working towards enhancing human health and capabilities by combining engineering and neurosciences.

Atharva Sahasrabudhe
Atharva Sahasrabudhe
Graduate Student

Graduate student

Jimin Park
Jimin Park
Graduate Student

Materials Scientist | Neural Engineer | Makgeolli Maker

Florian Koehler
Florian Koehler
Graduate Student

Neuroengineer

Dekel Rosenfeld
Dekel Rosenfeld
Postdoctoral Associate

Postocotoral associate, focusing on organ modulation such as on demand control of hormone release from adrenal glands and investigation of the gut-to-brain axis.

Polina Anikeeva
Polina Anikeeva
Professor in Materials Science and Engineering
Professor in Brain and Cognitive Sciences
Associate Director, Research Laboratory of Electronics

My goal is to combine the current knowledge of biology and nanoelectronics to develop materials and devices for minimally invasive treatments for neurological and neuromuscular diseases.

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