Transgene-free remote magnetothermal regulation of adrenal hormones

Abstract

The field of bioelectronic medicines seeks to modulate electrical signaling within peripheral organs, providing temporally precise control of physiological functions. This is usually accomplished with implantable devices, which are often unsuitable for interfacing with soft and highly vascularized organs. Here, we demonstrate an alternative strategy for modulating peripheral organ function, which relies on the endogenous expression of a heat-sensitive cation channel, transient receptor potential vanilloid family member 1 (TRPV1), and heat dissipation by magnetic nanoparticles (MNPs) in remotely applied alternating magnetic fields. We use this approach to wirelessly control adrenal hormone secretion in genetically intact rats. TRPV1-dependent calcium influx into the cells of adrenal cortex and medulla is sufficient to drive rapid release of corticosterone and (nor)epinephrine. As altered levels of these hormones have been correlated with mental conditions such as posttraumatic stress disorder and major depression, our approach may facilitate the investigation of physiological and psychological impacts of stress.

Publication
Science advances
Dekel Rosenfeld
Dekel Rosenfeld
Postdoctoral Associate

Postocotoral associate, focusing on organ modulation such as on demand control of hormone release from adrenal glands and investigation of the gut-to-brain axis.

Alexander W Senko
Data scientist at Livongo
Junsang Moon
Junsang Moon
Graduate Student

Graduate Student

Georgios Varnavides
Georgios Varnavides
Graduate Student

Full-time graduate student | Part-time design enthusiast | Aspiring cat herder.

Danijela Gregurec
Assistant Professor at Friedrich Alexander University
Florian Koehler
Florian Koehler
Graduate Student

Neuroengineer

Pohan Chiang
Assistant Professor at National Chiao Tung University
Michael G Christiansen
Postdoc at ETH Zurich (w/ Simone Schuerle)
Polina Anikeeva
Polina Anikeeva
Associate Professor in Materials Science and Engineering
Associate Professor in Brain and Cognitive Sciences
Associate Director, Research Laboratory of Electronics

My goal is to combine the current knowledge of biology and nanoelectronics to develop materials and devices for minimally invasive treatments for neurological and neuromuscular diseases.

Related