Remotely controlled proton generation for neuromodulation

Abstract

Understanding and modulating proton-mediated biochemical processes in living organisms have been impeded by the lack of tools to control local pH. Here, we design nanotransducers capable of converting noninvasive alternating magnetic fields (AMFs) into protons in physiological environments by combining magnetic nanoparticles (MNPs) with polymeric scaffolds. When exposed to AMFs, the heat dissipated by MNPs triggered a hydrolytic degradation of surrounding polyanhydride or polyester, releasing protons into the extracellular space. pH changes induced by these nanotransducers can be tuned by changing the polymer chemistry or AMF stimulation parameters. Remote magnetic control of local protons was shown to trigger acid-sensing ion channels and to evoke intracellular calcium influx in neurons. By offering a wireless modulation of local pH, our approach can accelerate the mechanistic investigation of the role of protons in biochemical signaling in the nervous system.

Publication
Nano Letters
Jimin Park
Jimin Park
Graduate Student

Materials Scientist | Neural Engineer | Makgeolli Maker

Anthony Tabet
Anthony Tabet
Graduate Student

Full-time graduate student | aspiring standup comedian

Junsang Moon
Junsang Moon
Graduate Student

Graduate Student

Pohan Chiang
Assistant Professor at National Chiao Tung University
Florian Koehler
Florian Koehler
Graduate Student

Neuroengineer

Atharva Sahasrabudhe
Atharva Sahasrabudhe
Graduate Student

Graduate student

Polina Anikeeva
Polina Anikeeva
Associate Professor in Materials Science and Engineering
Associate Professor in Brain and Cognitive Sciences
Associate Director, Research Laboratory of Electronics

My goal is to combine the current knowledge of biology and nanoelectronics to develop materials and devices for minimally invasive treatments for neurological and neuromuscular diseases.

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