Multifunctional fibers enable modulation of cortical and deep brain activity during cognitive behavior in macaques
Abstract
Recording and modulating neural activity in vivo enables investigations of neural circuits during behavior. However, there is a dearth of tools for simultaneous recording and localized receptor modulation in large animal models. We address this limitation by translating multifunctional fiber-based neurotechnology previously only available for rodent studies to enable cortical and subcortical neural modulation in macaques. We record single unit and local field potential activity before, during, and after intracranial GABA infusions in the premotor cortex and putamen. We apply state-space models to characterize changes in neural activity and investigate how neural activity evoked by a working memory task varies in the presence of local inhibition. The recordings provide detailed insight into the electrophysiological effect of neurotransmitter receptor modulation in both cortical and subcortical structures in an awake, behaving macaque. Our results demonstrate a first-time translation of multifunctional fibers for causal studies in behaving non-human primates.
Indie Garwood
Graduate Student
Graduate student developing neurotechnology to study anesthesia | Devoted dog + cat mom
Marc-Joseph Antonini
Postdoctoral Associate
Working towards enhancing human health and capabilities by combining engineering and neurosciences.
Polina Anikeeva
Professor in Materials Science and EngineeringProfessor in Brain and Cognitive SciencesAssociate Director, Research Laboratory of Electronics
My goal is to combine the current knowledge of biology and nanoelectronics to develop materials and devices for minimally invasive treatments for neurological and neuromuscular diseases.