Customizing Multifunctional Neural Interfaces through Thermal Drawing Process

Abstract

Fiber drawing enables scalable fabrication of multifunctional flexible fibers that integrate electrical, optical and microfluidic modalities to record and modulate neural activity. Constraints on thermomechanical properties of materials, however, have prevented integrated drawing of metal electrodes with low-loss polymer waveguides for concurrent electrical recording and optical neuromodulation. Here we introduce two fabrication approaches: (1) an iterative thermal drawing with a soft, low melting temperature (Tm) metal indium, and (2) a metal convergence drawing with traditionally non-drawable high Tm metal tungsten. Both approaches deliver multifunctional flexible neural interfaces with low-impedance metallic electrodes and low-loss waveguides, capable of recording optically-evoked and spontaneous neural activity in mice over several weeks. We couple these fibers with a light-weight mechanical microdrive (1g) that enables depth-specific interrogation of neural circuits in mice following chronic implantation. Finally, we demonstrate the compatibility of these fibers with magnetic resonance imaging (MRI) and apply them to visualize the delivery of chemical payloads through the integrated channels in real time. Together, these advances expand the domains of application of the fiber-based neural probes in neuroscience and neuroengineering.

Publication
bioRxiv
Marc-Joseph Antonini
Marc-Joseph Antonini
Postdoctoral Associate

Working towards enhancing human health and capabilities by combining engineering and neurosciences.

Atharva Sahasrabudhe
Atharva Sahasrabudhe
Graduate Student

Graduate student

Anthony Tabet
Anthony Tabet
Graduate Student

Full-time graduate student | aspiring standup comedian

Dekel Rosenfeld
Dekel Rosenfeld
Postdoctoral Associate

Postocotoral associate, focusing on organ modulation such as on demand control of hormone release from adrenal glands and investigation of the gut-to-brain axis.

Indie Garwood
Indie Garwood
Graduate Student

Graduate student developing neurotechnology to study anesthesia | Devoted dog + cat mom

Jimin Park
Jimin Park
Graduate Student

Materials Scientist | Neural Engineer | Makgeolli Maker

Mehmet Kanik
Senior Scientist on Advanced Materials, Impossible Foods
Andres Canales
Researcher at Advanced Silicon Group
Polina Anikeeva
Polina Anikeeva
Professor in Materials Science and Engineering
Professor in Brain and Cognitive Sciences
Associate Director, Research Laboratory of Electronics

My goal is to combine the current knowledge of biology and nanoelectronics to develop materials and devices for minimally invasive treatments for neurological and neuromuscular diseases.

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